Blood uric acid test  

Urine acid (UA) is the final product of purine catabolism in nucleoprotein and nucleic acid. It is divided into endogenous and exogenous.  Endogenous uric acid is produced by the catabolism of nucleic acid in the body.  Exogenous uric acid is produced by the catabolism of nucleic acids in food.  Uric acid is produced mainly in the liver and most of it is excreted through glomerular filtration in the urine.  Under normal conditions, uric acid in the body is in a dynamic equilibrium.  When kidney disease occurs, blood uric acid rises.  Blood uric acid detection is helpful for early diagnosis of kidney injury.  

Uric acid is oxidized by uricase to produce allantoin and hydrogen peroxide.  Hydrogen peroxide under the catalysis of catalase, 3.5- dichlorodihydroxybenzene sulfonic acid and 4- aminoantipyrine condensation to red quinone compounds.  The absorbance is read at 520nm, proportional to the uric acid concentration.  

The main causes of uric acid increase are: excessive intake of purines, excessive production of endogenous purines, and increased metabolism of purines.  Excess urate crystals deposit in tissues, mainly joints and cartilage, causing inflammation and gout.  However, a small number of gout patients have normal blood uric acid measurements during gout attacks.  Hyperuricemia is associated with increased blood uric acid and analgesia.  

The normal reference value of serum uric acid is 208 ~ 428μmol/L.  

During specimen collection, 2M1 of fasting venous blood was taken without anticoagulation, and serum was separated for determination.  Check the blood uric acid value, need fasting more than 8 hours to draw blood, generally require fasting after 12 o 'clock at night, but can drink water.